Pharmaceutical composition for controlled drug delivery system

Details Pharmaceutical composition for controlled drug delivery system Pharmaceutical composition for controlled drug delivery system

A - Human Necessities

61

K

A61K 9/22 (2006.01) A61K 9/00 (2006.01) A61K 9/24 (2006.01) A61K 9/26 (2006.01) A61K 9/32 (2006.01) A61K 9/36 (2006.01) A61K 9/20 (2006.01) A61K 9/28 (2006.01)

Patent

CA 2486794

The present invention describes a novel controlled release multilayer composition that is capable of delivering a first active agent from one layer immediately followed by continuous controlled delivery of second active agent from matrix forming layer while the dosage form floats and is retained in the fluid of the environment. The floating bilayer system comprises of immediate release layer containing one active agent and a disintegrating agent whereas second floating matrix forming layer comprises a gas generating component, a gelling agent, and a second active agent. The present invention relates more particularly to a controlled release fluoroquinolone compositions, which maintain a therapeutically effective blood concentration of fluoroquinolone for duration with once a day administration.

L'invention porte sur une nouvelle composition multicouche à libération progressive libérant un premier agent actif d'une couche immédiatement suivi de la libération progressive continue d'un deuxième agent actif provenant d'une couche formant une matrice, tandis que la forme posologique qui flotte et retenue dans le fluide environnant. Le système bicouche flottant comporte une couche à libération immédiate contenant un agent actif et un agent désintégrateur et une deuxième couche formant une matrice flottante comprenant un élément gazogène, un gélifiant, et un deuxième agent actif. L'invention porte plus particulièrement sur une composition à libération progressive de fluoroquinolone qui maintient une concentration sanguine efficace de fluoroquinolone permettant une administration quotidienne.

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