A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/30 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 31/785 (2006.01) A61K 38/22 (2006.01) A61K 38/23 (2006.01) A61K 38/28 (2006.01) A61K 47/32 (2006.01) A61K 47/46 (2006.01) A61P 43/00 (2006.01) A61K 9/28 (2006.01)
Patent
CA 2472449
The present invention relates to an agent for inhibiting decomposition of a biologically active peptide by a digestive enzyme, which is aminoalkyl methacrylate copolymer E as an effective ingredient, and an agent for reducing viscosity of the gastrointestinal mucosa and mucous layers distributed over this mucosa. The present invention relates to a method for inhibiting decomposition of a biologically active peptide by a digestive enzyme, or a method for reducing viscosity of the gastrointestinal mucosa and/or mucous layers distributed over the mucosa, by administration of aminoalkyl methacrylate copolymer E. Furthermore, the present invention relates to a pharmaceutical composition for oral use with improved absorption, which comprises a biologically active peptide and aminoalkyl methacrylate copolymer E. Excellent oral absorption of a biologically active peptide that were considered difficult to absorb by oral administration in the past, can be realized based on the ability to inhibit decomposition of a biologically active peptide, the ability to reduce viscosity of the gastrointestinal mucosa and/or mucous layers distributed over this mucosa, and the ability to improve permeability of a biologically active peptide in the gastrointestinal mucosa and/or mucous layers of the pharmaceutical composition of the present invention.
L'invention concerne des inhibiteurs de dégradation d'un peptide actif au niveau physiologique avec une enzyme digestive, lesquels comprennent un copolymère de méthacrylate aminoalkyle E en tant qu'ingrédient actif, des agents diminuant la viscosité pour une muqueuse du tube digestif et/ou des couches muqueuses réparties sur le tube digestif, lesquels comprennent un copolymère de méthacrylate aminoalkyle E en tant qu'ingrédient actif, ainsi que des compositions médicamenteuses permettant d'améliorer l'absorption orale, lesquelles comprennent un peptide actif au niveau physiologique et un copolymère de méthacrylate aminoalkyle E. Ces compositions permettent d'obtenir une excellente capacité d'absorption orale pour un peptide actif au niveau physiologique, lequel peptide est considéré comme pouvant être difficilement absorbé par voie orale.
Nakanishi Kiyo
Takemura Shigeo
Tsutsui Yuuki
Watanabe Shunsuke
Astellas Pharma Inc.
Dennison Associates
Yamanouchi Pharmaceutical Co. Ltd.
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