A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/16 (2006.01) A61K 9/08 (2006.01) A61K 9/10 (2006.01) A61K 9/14 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 31/663 (2006.01) A61K 47/12 (2006.01) A61K 47/32 (2006.01)
Patent
CA 2415643
The present invention presents a pharmaceutical composition for oral use with improved absorption, which comprises drug, aminoalkyl methacrylate copolymer E, and acidic substance, wherein said 3 components are brought together and at least this polymer and this acidic substance are uniformly mixed, and a method of improving oral absorption by using this pharmaceutical composition. Moreover, the present invention presents an agent for improving oral absorption that increases drug permeability of the digestive tract mucous membrane and/or mucous layer present on the surface of this membrane, whose active ingredient is aminoalkyl methacrylate copolymer E. In addition, the present invention presents an oral agent for improving absorption by increasing drug permeability of the digestive tract mucous membrane and/or the mucous layer distributed over this mucous membrane, whose effective component is aminoalkyl methacrylate copolymer E.
Cette invention concerne : une composition pharmaceutique à absorbabilité per os améliorée, comprenant un médicament, in aminoalkyl méthacrylate copolymère E et une substance acide dans laquelle les trois composants sont adjacents les uns aux autres et où au moins le copolymère et la substance acide sont dispersés uniformément ; une méthode permettant d'améliorer l'absorbabilité per os au moyen de ladite composition ; et un améliorateur d'absorbabilité per os améliorant la pénétration du médicament dans la muqueuse gastro-intestinale et/ou dans la couverture muqueuse présente à la surface de ladite muqueuse, et qui renferme un aminoalkyl méthacrylate copolymère E comme principe actif.
Kondo Hiromu
Nakanishi Kiyo
Sako Kazuhiro
Sawada Toyohiro
Takemura Shigeo
Astellas Pharma Inc.
Dennison Associates
Yamanouchi Pharmaceutical Co. Ltd.
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