Pharmaceutical composition for periodic administration

Details Pharmaceutical composition for periodic administration Pharmaceutical composition for periodic administration

A - Human Necessities

61

K

A61K 45/00 (2006.01) A61K 31/381 (2006.01) A61P 15/00 (2006.01) C07D 333/56 (2006.01)

Patent

CA 2352461

In the case of administering an estrogen antagonist for treating or preventing endometriosis and/or menstrual abnormality, it is needless to administer the drug constantly and continuously during the period with a need of the treatment or prevention (i.e., chronic administration) but almost comparable therapeutic effects to those of the chronic administration can be achieved by continuously administering for 5 to 13 days from the menstrual period to immediately before ovulation (i.e., periodic administration). Moreover, the periodic administration is almost completely free from such side effects as observed in the case of the chronic administration of the estrogen antagonist. Thus, the periodic administration is a useful method for administering the estrogen antagonist for treating or preventing endometriosis and/or menstrual abnormality.

Dans le cas d'un antagoniste d'oestrogène destiné au traitement ou à la prévention d'une endométriose et/ou d'un dysfonctionnement menstruel (administration permanente). En effet, on peut obtenir des effets thérapeutiques quasi identiques en administrant le médicament de façon continue pendant 5 à 13 jours du cycle menstruel jusqu'au jour précédant immédiatement l'ovulation (administration périodique). Par ailleurs, l'administration périodique ne s'accompagne de pratiquement aucun des effets secondaires observables dans le cas d'une administration permanente. Ainsi, l'administration périodique constitue un moyen utile d'administrer un antagoniste d'oestrogène pour le traitement ou la prévention d'une endométriose ou d'un dysfonctionnement menstruel.

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