A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/275 (2006.01) A61K 31/42 (2006.01) A61K 31/655 (2006.01)
Patent
CA 2202904
A pharmaceutical composition for prophylaxis or treatment of Type I allergic diseases which comprises as an active ingredient an anilide compound represented by the general formula (I) (see formula I) [wherein R1 is a trifluoromethyl group, a halogen atom or a cyano group, R2 is a hydrogen atom or a straight or branched C1 - C4 alkyl group and R3 is a group of the formula (II) or (III) (see formula II or III) (wherein R4 is a straight or branched C1 - C4 alkyl group, a straight or branched C2 - C6 alkenyl group, a straight or branched C2 - C6 alkynyl group or a C2 - C6 cycloalkyl group) or a stereoisomer thereof or a physiologically acceptable salt thereof. The present composition remarkably inhibits the production of IgE, which is the direct cause of Type I allergic diseases, and it can radically prevent or cure Type I allergic diseases.
Composition destinée à prévenir ou traiter les maladies allergiques de type I, contenant en tant que principe actif un composé anilide de formule générale (I), un stéréoisomère dudit composé ou un sel physiologiquement acceptable dudit composé. Dans ladite formule, R1 représente trifluorométhyle, halogéno ou cyano; R2 représente hydrogène ou alkyle C1-C4 linéaire ou ramifié et R3 représente un groupe de formule générale (II) ou (III) dans laquelle R4 représente alkyle C1-C4 linéaire ou ramifié, alcényle C2-C7 linéaire ou ramifié, alcynyle C2-C6 linéaire ou ramifié ou cycloalkyle C3-C7. Ladite composition peut prévenir ou traiter de manière radicale des maladies allergiques de type I en inhibant la production d'IgE en tant que cause directe de ces maladies.
Amano Yukio
Mizushima Yuko
Ogata Kenji
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Hoechst Pharmaceuticals & Chemicals K.k.
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