Pharmaceutical composition for pulmonary delivery

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/12 (2006.01) A61K 9/16 (2006.01) A61K 31/137 (2006.01) A61K 31/46 (2006.01) A61K 31/557 (2006.01) A61K 31/58 (2006.01)

Patent

CA 2399367

A dry particulate pharmaceutical composition for pulmonary administration is prepared by spray-drying a hydrophobic active agent (e.g. declomethasone dipropionate) with a small quantity of pharmaceutically acceptable hydrophilic polymer (e.g. poly(vinyl)alcohol). This mitigates aggregation of the particles of active agent, which otherwise limits the desirable fine particle dose available.

L'invention concerne une composition pharmaceutique de particules sèches destinée à être administrée par voie pulmonaire, préparée par séchage par atomisation d'un agent actif hydrophobe (du dipropionate de béclométhasone, par exemple) avec une petite quantité d'un polymère hydrophile pharmaceutiquement acceptable (du poly(alcool de vinyle), par exemple). Cette méthode permet de limiter l'agrégation de particules d'agent actif, ce qui dans le cas contraire limite la dose disponible souhaitée de particules fines.

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