Pharmaceutical composition for solubility enhancement of...

A - Human Necessities – 61 – K

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A61K 47/00 (2006.01)

Patent

CA 2529606

The present invention provides a pharmaceutical composition comprising a drug and polyethylene glycol, wherein the ratio of polyethylene glycol to drug by weight is from about 0.2:1 to about 10:1, and the polyethylene glycol has a melting point of at least 37oC. The pharmaceutical compositions of the invention exhibit rapid dissolution upon contact with physiological solvents, such as water, saliva or gastrointestinal fluids.

La présente invention concerne une composition pharmaceutique comprenant un médicament et un polyéthylène glycol, le rapport de polyéthylène glycol sur médicament en masse étant compris entre environ 0.2:1 et environ 10:1 et, ce polyéthylène glycol possède un point de fusion d'au moins 37 degrés Celsius. Ces compositions pharmaceutiques présentent une dissolution rapide au contact de solvants physiologiques, tels que de l'eau, de la salive ou des fluides gastro-intestinaux.

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