Pharmaceutical composition for the controlled release of...

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/28 (2006.01) A61K 9/16 (2006.01) A61K 9/26 (2006.01) A61K 9/32 (2006.01) A61K 9/50 (2006.01) A61K 31/445 (2006.01) A61K 47/00 (2006.01)

Patent

CA 2742680

Disclosed is a pharmaceutical composition for release control comprising a plurality of particles for release control. The plurality of particles for release control comprise a core material containing methylphenidate and a polymer coating layer for release control formed on the core material. The plurality of particles for release control are divided into two or more groups based on the average thickness of the polymer coating layer for release control. The particle groups are identical in terms of the composition of the polymer in the polymer coating layer, but are different in terms of the average thickness of the coated layer. The pharmaceutical composition for release control according to the present invention may control the relase pattern of methylphenidate contained in the core material as desired, and can be used as an oral formulation in a variety of forms such as orally disintegrating tablets, etc. 41

L'invention concerne une composition pharmaceutique à libération progressive qui comprend une matière de noyau contenant du méthylphénidate, et une pluralité de particules à libération progressive qui contiennent une couche d'enrobage polymère à libération progressive, formée sur la matière de noyau. La pluralité des particules à libération progressive est divisée en deux ou davantage de groupes selon l'épaisseur moyenne de la couche d'enrobage polymère à des fins de libération progressive. Les groupes de particules sont identiques du point de vue de la composition du polymère dans la couche d'enrobage polymère, mais différents du point de vue de l'épaisseur moyenne de la couche d'enrobage. La composition pharmaceutique à libération progressive de l'invention permet de réguler de manière voulue le motif de libération du méthylphénidate contenu dans la matière de noyau, et peut être utilisée comme formulation orale sous diverses formes, p. ex. comprimés à dissolution rapide, etc.

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