Pharmaceutical composition for the treatment of bone fracture

Details Pharmaceutical composition for the treatment of bone fracture Pharmaceutical composition for the treatment of bone fracture

A - Human Necessities

61

K

A61K 31/426 (2006.01) A61P 19/00 (2006.01)

Patent

CA 2572897

Disclosed herein is a composition for the treatment bone fracture comprising N- hydroxy-4-{5- [4- (5-isopropyl-2- methyl-1, 3-thiazol-4-yl)phenoxy] pentoxyl - benzamidine, 4-{5- [4- (5-isopropyl-2-methyl--l, 3-thiazol-4- yl)phenoxy]pentoxy}- benzamidine or pharmaceutically acceptable salts thereof as a medicinally effective ingredient. The composition of the present invention can significantly reduce the volume of bony callus, increase bony density and strength of bony callus, and decrease the contents of connective tissue and cartilage tissue in bony callus, and thus promote loss and ossification of the bony callus formed during the fracture healing process. Therefore, the composition of the present invention is useful for the treatment of bone fracture.

L'invention concerne une composition servant à traiter des fractures osseuses et contenant N-hydroxy-4-{5-[4-(5-isopropyl-2-méthyl-1,3-thiazol-4-yl)phénoxy]pentoxy-benzamidine, 4-{5-[4-(5-isopropyl-2-méthyl-1,3-thiazol-4-yl)phénoxy]pentoxy}- benzamidine ou leurs sels acceptables sur le plan pharmaceutique en tant qu'ingrédient actif sur le plan médical. Cette composition peut réduire considérablement le volume du cal osseux, augmenter la densité osseuse et la résistance du cal et diminuer la teneur en tissu conjonctif et en tissu cartilagineux du cal osseux, ce qui favorise la perte et l'ossification du cal osseux qui s'est formé pendant le processus de guérison de la fracture. Cette composition est, par conséquent, utile pour traiter les fractures osseuses.

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