A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/07 (2006.01) A61K 31/355 (2006.01) A61K 31/59 (2006.01)
Patent
CA 2209205
9-Cis-retinoic acid-.alpha.-tocopherol esters, pharmaceutical compositions containing the same and use of the same as a medicine for the treatment of leukemia, in particular, the remission of leukemia are provided and a combined use of a 9-cis-retinoic acid-.alpha.-tocopherol ester and either 1.alpha.,25-dihydroxyvitamin D3 or 9-cis-retinoic acid exhibits a synergistic effect in the treatment of leukemia without any side effects caused by 1.alpha.,25-dihydroxyvitamin D3 or 9-cis-retinoic acid.
Esters d'alpha-tocophérol et d'acide 9-cis-rétinoïque; compositions pharmaceutiques à base de ces esters et leur emploi comme médicament pour le traitement de la leucémie, notamment pour sa rémission; utilisation combinée d'un ester d'alpha-tocophérol et d'acide 9-cis-rétinoïque avec, soit la 1alpha,25-dihydroxyvitamine D3, soit l'acide 9-cis-rétinoïque pour l'obtention d'un effet synergiste dans le traitement de la leucémie sans les effets secondaires causés par la 1alpha,25-dihydroxyvitamine D3 ou l'acide 9-cis-rétinoïque.
Honma Yoshio
Inomata Kohei
Kanatani Yasuhiro
Kishiye Takao
Makishima Makoto
Nisshin Flour Milling Co. Ltd.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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