Pharmaceutical composition for thrombin peptide derivatives

Details Pharmaceutical composition for thrombin peptide derivatives Pharmaceutical composition for thrombin peptide derivatives

A - Human Necessities

61

K

A61K 38/48 (2006.01) A61K 31/198 (2006.01) A61K 47/12 (2006.01) A61P 17/02 (2006.01)

Patent

CA 2551525

Disclosed are pharmaceutical compositions comprising a thrombin peptide derivatives and a chelating agent and/or a pharmaceutically acceptable thiol~containing compound. The pharmaceutical compositions optionally further comprise an antioxidant. Also, disclosed are methods for activating the non~proteolytically activated thrombin receptor in a subject in need of such treatment. The methods comprise the step of administering an effective amount of a thrombin peptide derivative in the pharmaceutical composition described above.

L'invention concerne des compositions pharmaceutiques contenant des dérivés pharmaceutiques et un agent de chélation et/ou un composé contenant un thiol acceptable d'un point de vue pharmaceutique. Les compositions pharmaceutiques contiennent également, éventuellement, un antioxydant. L'invention concerne en outre des méthodes d'activation du récepteur de la thrombine non activé de manière protéolytique chez un sujet nécessitant un tel traitement. Lesdites méthodes consistent à administrer une quantité efficace d'un dérivé peptidique de la thrombine dans ladite composition pharmaceutique.

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