Pharmaceutical composition for treating or preventing hcv...

A - Human Necessities – 61 – K

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A61K 38/21 (2006.01) A61K 45/00 (2006.01) A61P 1/16 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2652333

The inventors examined an anti-HCV effect of an SPT inhibitor and/or interferon using an HCV subgenomic replicon cell FLR3-1 or an HCV infected chimeric mouse. As a result, it was found that myriocin, an SPT inhibitor, or a compound represented by the formula (III) can be a novel therapeutic agent for HCV infection and that a higher HCV replication inhibitory effect can be obtained by concomitantly using the SPT inhibitor and interferon.

Les présents inventeurs ont examiné l'effet anti-VHC d'un inhibiteur de la SPT et/ou d'un interféron en utilisant une cellule FLR3-1 de réplicon sous-génomique du VHC ou une souris chimérique infectée par le VHC. En conséquence, il a été découvert que la myriocine, un inhibiteur de la SPT, ou un composé représenté par la formule (III) peut représenter un nouvel agent thérapeutique utile pour l'infection par le VHC et qu'un effet inhibiteur plus important de la réplication du VHC peut être obtenu en utilisant de façon concomitante l'inhibiteur de la SPT et l'interféron.

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