Pharmaceutical composition for treatment of diarrhea

A - Human Necessities – 61 – K

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A61K 38/06 (2006.01) A61K 31/198 (2006.01) A61K 38/05 (2006.01) A61K 38/12 (2006.01)

Patent

CA 2402811

A pharmaceutical composition comprising a colon-specific delivery system and cysteine, cysteine derivatives and/or cysteine-containing compounds, is described. Examples of the active ingredients are cysteine, acetylcysteine, cystine and glutathione. The cysteine, cysteine derivatives and cysteine- containing compounds may be used in a medicament for therapeutic, prophylactic and relapse prophylactic treatment of Clostridium difficile associated diarrhea/disease. A method of therapeutic, prophylactic and relapse prophylactic treatment of Clostridium difficile associa ted diarrhea/disease is also disclosed.

L'invention concerne une composition pharmaceutique comprenant un système de délivrance spécifique au colon et de la cystéine, des dérivés de cystéine et/ou des composés contenant de la cystéine. Citons comme exemples d'ingrédients actifs la cystéine, l'acétylcystéine, la cystine et les composés de glutathion. La cystéine, les dérivés de cystéine et les composés de cystéine peuvent être utilisés dans un médicament destiné au traitement thérapeutique, prophylactique et de prévention de toute de rechute du Clostridium difficile associé à une diarrhée/maladie. L'invention concerne égalament un procédé thérapeutique, un traitement prophylactique et de prévension de toute rechute du Clostridium difficile associé à une diarrhée/maladie.

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