C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/27 (2006.01) A61K 31/5578 (2006.01) A61K 31/559 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01) C07C 405/00 (2006.01) C07D 207/24 (2006.01) C07D 263/24 (2006.01) C07D 333/46 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2454584
Drugs for topical administration which contain an EP4 agonist as the active ingredient for preventing and/or treating diseases in association with bone mass loss. EP4 agonists typified by compounds with the prostaglandin skeleton have an effect of promoting osteogenesis. Thus, topical administration thereof is highly useful in preventing and/or treating diseases in association with bone mass loss (for example, bone diseases such as primary osteoporosis, secondary osteoporosis, bone metastasis of cancer, hypercalcemia, Behcet~s disease, bone loss and bone necrosis, postoperative osteogenesis, alternative therapy for bone transplantation).
L'invention concerne des médicaments d'application topique qui contiennent un agoniste de EP¿4? en tant que principe actif et qui sont destinés à prévenir et/ou à traiter des maladies associées à une perte de la masse osseuse. Les agonistes de EP¿4? typifiés par des composés à ossature prostaglandinique ont un effet de promotion de l'ostéogenèse. Par conséquent, l'application topique de ces médicaments convient particulièrement à la prévention et/ou au traitement de maladies associées à une perte de la masse osseuse, notamment des maladies osseuses telles que l'ostéoporose primaire, l'ostéoporose secondaire, la métastase osseuse du cancer, l'hypercalcémie, la maladie de Bechet, la perte osseuse et la nécrose osseuse, l'ostéogenèse postopératoire ainsi que pour une thérapie alternative de transplantation osseuse.
Abe Nobutaka
Kambe Tohru
Kobayashi Kaoru
Maruyama Takayuki
Maruyama Toru
Ono Pharmaceutical Co. Ltd.
Riches Mckenzie & Herbert Llp
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