Pharmaceutical composition having an endoproteolytic...

Details Pharmaceutical composition having an endoproteolytic... Pharmaceutical composition having an endoproteolytic...

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A01K 67/027 (2006.01) A61K 38/48 (2006.01) C07K 14/755 (2006.01) C07K 14/82 (2006.01) C07K 16/32 (2006.01) C07K 16/40 (2006.01) C12N 5/10 (2006.01) C12N 9/48 (2006.01) C12N 9/62 (2006.01) C12N 9/64 (2006.01) C12N 15/62 (2006.01) C12P 7/64 (2006.01) C12P 21/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2069929

The invention is based on the finding that furin belongs to a family of endoproteolytically active enzymes and relates to a process for the in vitro cleavage of a protein by treating the protein in the prescence of Ca2+ ions with furin or a furin-like enzyme, or an endoproteolytically active fragment, derivative or fusion protein of furin or furin-like enzyme. The invention can be used for the (micro)biological production of a protein by culturing genetically engineered cells expressing a proform of the protein as well as furin or a furin-like enzyme and isolating the protein formed. The invention also relates to a pharmaceutical composition comprising one or more pharmaceutically acceptable carriers, diluents or adjuvants, as well as an endoproteolytically active amount of furin or a furin-like enzyme, or a fragment or derivative of furin or furin-like enzyme having an endoproteolytic activity.

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