Pharmaceutical composition having an improved water solubility

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 413/12 (2006.01) A61K 9/10 (2006.01) A61K 9/14 (2006.01) A61K 31/422 (2006.01) A61K 47/20 (2006.01) A61K 47/26 (2006.01) A61K 47/28 (2006.01) A61K 47/32 (2006.01) A61K 47/38 (2006.01) A61K 47/40 (2006.01) A61P 35/00 (2006.01) A61K 9/16 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2431319

Solid dispersions containing an HER2 inhibitor which is hardly or not soluble in water and a hydrophilic polymer. These solid dispersions have been improved in the solubility of the HER2 inhibitor, oral absorbability and absorbability in blood.

La présente invention concerne des dispersions solides contenant un inhibiteur de HER2 qui est difficilement soluble voire non soluble dans l'eau et un polymère hydrophile. Ces dispersions solides présentent une solubilité de l'inhibiteur de HER2, une absobabilité par voie orale et sanguine améliorées.

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