Pharmaceutical composition in the form of a hydrogel for...

A - Human Necessities – 61 – K

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A61K 9/70 (2006.01) A61K 31/565 (2006.01) A61K 47/14 (2006.01)

Patent

CA 2523734

The invention relates to a pharmaceutical composition in the form of a hydrogel comprising a carbonic acid ester, a C2-C4 alkyl alcohol, a active substance and a polymer matrix. The invention also relates to the use of a carbonic acid aster as a transdermal permeation agent for an active substance in a pharmaceutical composition in the form of a hydrogel, said composition comprising a polymer matrix and a C2-C4 alkyl alcohol. The invention also relates to a perspiration-resistant composition in the form of a hydrogel, comprising an acrylic polymer combined with a cellulose derivative.

L'invention concerne une composition pharmaceutique se présentant sous la forme d'un hydrogel, contenant un diester d'acide carboxylique, un alcool C¿2?-C¿4?-alkyl, un agent actif et une matrice polymère. L'invention concerne également l'utilisation d'un diester d'acide carboxylique en tant que médiateur de perméation transdermique d'un agent actif dans une composition pharmaceutique se présentant sous la forme d'un hydrogel, ladite composition contenant une matrice polymère et un alcool C¿2?-C¿4?-alkyl. L'invention concerne par ailleurs une composition antisudorale se présentant sous la forme d'un hydrogel, contenant un polymère acrylique combiné à un dérivé de cellulose.

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