A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/19 (2006.01) A61K 47/00 (2006.01)
Patent
CA 2537610
The invention relates to a pharmaceutical composition prepared by freeze- drying in vacuo, containing oxaliplatin as the active component and a pharmaceutically acceptable carrier, wherein the carrier is at least one alcoholic sugar of non-animal origin, the weight ratio of oxaliplatin to the alcoholic sugar of non-animal origin or alcoholic sugars of non-animal origin being 1:3 to 1:7. The invention also relates to the method of manufacturing of said composition and to the use of this composition in the treatment of tumors sensitive to oxaliplatin.
La présente invention concerne une composition pharmaceutique préparée par lyophilisation sous vide. Cette composition contient de l'oxaliplatine en tant que principe actif et un excipient acceptable sur le plan pharmaceutique. Cet excipient est, au moins, un sucre d'alcool d'origine non animale, le rapport pondéral d'oxaliplatine sur le sucre d'alcool ou sur les sucres d'alcool d'origine non animale étant de 1:3 à 1:7. Cette invention concerne également un procédé permettant de fabriquer une telle composition ainsi que l'utilisation de cette composition dans le traitement de tumeurs sensibles à l'oxaliplatine.
Boleslav Jan
Brzobohata Hana
Kakrda Milan
Kysilka Vladimir
Matejkova Bozena
Norton Rose Or S.e.n.c.r.l.,s.r.l./llp
Pliva-Lachema A.s.
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