Pharmaceutical composition of dihydropyridine compound

Details Pharmaceutical composition of dihydropyridine compound Pharmaceutical composition of dihydropyridine compound

A - Human Necessities

61

K

167/229

A61K 31/675 (2006.01) A61K 9/14 (2006.01) A61K 9/18 (2006.01) A61K 31/44 (2006.01) A61K 31/665 (2006.01) A61K 47/38 (2006.01)

Patent

CA 1332152

ABSTRACT OF THE DISCLOSURE A parmaceutical composition comprising: a 1:1 solvate of 5-(5,5-dimethyl-1,3,2-dioxaphosphorinane-2-yl)-1,4- dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridine carboxylic acid 2-(phenyl(phenylmethyl)amino) ethyl ester P-oxide hydrochloride-ethanol (NZ-105) and hydroxypropyl- methylcellulose acetate succinate is disclosed. The composition can easily be prepared into tablets, capsules, granules, and powders, which exhibit an enhanced bioavailability, e.g. provides a high blood concentration of the active component NZ-105 and ensures a high total drug absorption.

600631

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