Pharmaceutical composition to protect an animal against a...

Details Pharmaceutical composition to protect an animal against a... Pharmaceutical composition to protect an animal against a...

A - Human Necessities

61

K

A61K 35/74 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2749075

The invention pertains to a pharmaceutical composition to protect an animal against a disorder arising from an infection with a bacterium that belongs to the group of nocardioform actinomycetes having the ability to survive within macrophages of the animal, comprising live bacteria of a nocardioform actinomycetes species, the live bacteria being attenuated by inactivation of a gene that encodes a protein involved in methylhexahydroindanedione propionate degradation, and a pharmaceutically acceptable carrier for these live bacteria.

L'invention porte sur une composition pharmaceutique destinée à protéger un animal contre un trouble causé par une infection par une bactérie qui appartient au groupe des actinomycètes nocardioformes ayant la capacité de survivre dans des macrophages de l'animal, comprenant des bactéries vivantes de l'espèce actinomycète nocardioforme, les bactéries vivantes étant atténuées par l'inactivation d'un gène codant pour une protéine impliquée dans la dégradation du propionate de méthylhexahydroindanedione, et un vecteur pharmaceutiquement acceptable pour ces bactéries vivantes.

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