C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/87 (2006.01) A61K 31/70 (2006.01) A61K 45/06 (2006.01) A61K 47/34 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C12N 15/88 (2006.01)
Patent
CA 2231064
A pharmaceutical composition useful for nucleic acid transfection is disclosed. The composition contains, in addition to a nucleic acid and at least one transfection agent, at least one compound that combines DNA binding properties with a nuclear DNA vectorisation capability, and preferably belongs to the HMG ("High mobility group") protein family. The use of said composition for in vitro, ex vivo and/or in vivo nucleic acid transfer is also disclosed.
La présente invention concerne une composition pharmaceutique utile pour la transfection d'un acide nucléique caractérisée en ce qu'elle contient outre ledit acide nucléique et au moins un agent de transfection, au moins un composé associant des propriétés de fixation de l'ADN à une capacité de vectorisation nucléaire de cet ADN, ce dernier appartenant de préférence à la famille des protéines HMG ("High mobility group"). Elle se rapporte en outre à l'utilisation de ladite composition pour le transfert in vitro, ex vivo et/ou in vivo d'acides nucléiques.
Blanche Francis
Cameron Beatrice
Crouzet Joel
Thuillier Vincent
Rhone-Poulenc Rorer S.a.
Robic
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