Pharmaceutical composition which improves in vivo gene transfer

Details Pharmaceutical composition which improves in vivo gene transfer Pharmaceutical composition which improves in vivo gene transfer

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/77 (2006.01) A61K 31/785 (2006.01)

Patent

CA 2473212

The invention relates to a pharmaceutical composition which combines a tetrafunctional copolymer with a nucleic acid, said copolymer having formula I (namely a poloxamine) and preferably taking the form of one of the cationic mineral or organic salts thereof. The inventive composition can be used to improve in vivo gene transfer.

L'invention a pour objet une composition pharmaceutique associant à un acide nucléique un copolymère tétrafonctionnel de formule I (à savoir une poloxamine), de préférence sous la forme d'un de ses sels organique ou minéral cationique, utile pour améliorer le transfert de gène in vivo.

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