Pharmaceutical compositions

Details Pharmaceutical compositions Pharmaceutical compositions

A - Human Necessities

61

K

167/223, 260/266

A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 241/08 (2006.01)

Patent

CA 2033203

- 33 - ABSTRACT PHARMACEUTICAL COMPOSITIONS Compounds of formula II: Image wherein n is 0, 1 or 2, R1, R2, R3 and R4 are each separately selected from hydrogen, unsubstituted acyclic aliphatic hydrocarbon groups having a maximum of six carbon atoms and C1-6 alkyl groups substituted by a hydroxy group or a C1-6 alkoxy group, or one of R1 and R2 and one of R3 and R4 is hydrogen and the others are a trimethylene, tetramethylene or pentamethylene bridging group, and R5 is hydrogen or an unsubstituted acyclic aliphatic hydrocarbon group having a maximum of six carbon atoms, but with the provisos that (a) when n is 0 the combinations R1 = R2 = R3 = R4 = R5 = H and R1 = R2 = R3 = R5 = H, R4 = methyl are excluded, and (b) when n is 0, R1, R3 and R5 are each hydrogen, and each of R2 and R4 is other than hydrogen the compound is in other than the meso or erythro configuration, or a salt thereof formed with a physiologically acceptable inorganic or organic acid, are of use in therapy, particularly as cardioprotective agents.

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