Pharmaceutical compositions

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/16 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01) A61K 9/50 (2006.01)

Patent

CA 2360655

A pharmaceutical composition for slow release of active ingredient in the gastrointestinal tract, comprising a plurality of active ingredient-containing particles coated with a material insoluble in gastric and intestinal juices, where the particles have as core a homogeneous mixture comprising an active pharmaceutical ingredient and a polymer insoluble in gastric and intestinal juices, with an average internal pore diameter not exceeding 35 µm, makes efficient and pH-independent delaying of release possible even with comparatively small amounts of polymer. It is additionally distinguished by a long shelf life and is particularly suitable also for nonspherical particles.

L'invention concerne une composition pharmaceutique pour la libération lente de principe actif dans le tractus gastro-intestinal, contenant plusieurs particules recouvertes d'un matériau renfermant le principe actif et insoluble dans les sucs gastriques et intestinaux. Ces particules présentent un noyau constitué d'un mélange homogène qui contient un principe actif pharmaceutique et un polymère insoluble dans les sucs gastriques et intestinaux, présentant un diamètre moyen intérieur des pores d'au maximum 35 mu m. Cette composition pharmaceutique permet une libération retardée, efficace et indépendante du pH, même avec des quantités de polymère relativement faibles. Elle se distingue en outre par une grande stabilité au stockage et convient en particulier à des particules non sphériques.

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