Pharmaceutical compositions

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/107 (2006.01) A61K 9/48 (2006.01) A61K 31/436 (2006.01) A61K 38/13 (2006.01) A61K 47/12 (2006.01)

Patent

CA 2200967

This invention provides a microemulsion pre-concentrate comprising a difficultly soluble active agent and a carrier medium comprising: 1) a hydrophilic phase which comprises dimethylisosorbide and/or a lower alkyl alkanoic ester, 2) a lipophilic phase, and 3) a surfactant. The active agent may be a cyclosporin or a macrolide. In another aspect, this invention provides a pharmaceutical composition for enteral or parenteral administration comprising a macrolide and an acid.

Préconcentré microémulsionné comportant un agent actif difficilement soluble et un milieu excipient comportant (1) une phase hydrophile comprenant un diméthylisosorbide et/ou un ester alcanoïque d'alkyle inférieur, (2) une phase lipophile, et (3) un tensioactif. L'agent actif peut être une cyclosporine ou un macrolide. On a également prévu une composition pharmaceutique destinée à une administration entérale ou parentérale comportant un macrolide et un acide.

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