Pharmaceutical compositions and combinations for the...

A - Human Necessities – 61 – K

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A61K 31/216 (2006.01) A61K 31/192 (2006.01) A61P 31/12 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2312644

The subject invention is directed to a pharmaceutical composition for the treatment or prophylaxis of disorders related to HIV and retrovirus, said composition comprising an effective amount of a compound of formula I (see formula I) wherein Ar represents aryl, which is unsubstituted or substituted with halo, hydroxyl or C1-6-alkoxyl; A represents C1-6-alkylene, C2-6-alkenylene or C2-6-alkynylene; m is an integer from 0 to 6; and B represents hydrogen, C1-6-alkyl or aryl, said aryl is unsubstituted or substituted with halo, hydroxyl, C1-6-alkyl, C2-6-alkenyl or C2-6-alkynyl; or pharmaceutically acceptable salts thereof, together with a pharmaceutically acceptable carrier. The invention is also directed to a pharmaceutical composition for use in the inhibition of HIV and retrovirus replication comprising an effective amount of a compound of formula I. The invention is further directed to a combination of compound of formula I and other antiviral agents.

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