Pharmaceutical compositions and devices for their...

A - Human Necessities – 61 – K

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167/158, 222/55

A61K 9/72 (2006.01) A61J 7/00 (2006.01) A61K 9/12 (2006.01) B65D 83/14 (2006.01) B65D 83/44 (2006.01)

Patent

CA 2273835

A device for providing pharmaceutical doses comprising a container, filled with a pharmaceutical composition including a pharmaceutically active agent in a solution of liquified 1,1,1,2-tetrafluoroethane (HFC-134a), or 1,1,1,2,3,3,3- heptafluoropropane (HFC-227) and a carrier. The carrier can be a pharmaceutically acceptable alcohol, polyol, (poly)alkoxy derivative, fatty acid alkyl ester, polyalkylene glycol, or dimethyl sulphoxide. The device includes valve means arranged for delivering aerosol doses of said pharmaceutical composition to the exterior of the container, and at least a portion of the device is formed from a polyester.

L'invention concerne un dispositif destiné à administrer des doses pharmaceutiques, comprenant un récipient rempli d'une composition pharmaceutique contenant un agent pharmaceutique actif, dans une solution de 1,1,1,2-tetrafluoroéthane (HFC-13A) ou de 1,1,1,2,3,3,3-heptafluoropropane (HFC-227) liquéfiés et un excipient. L'excipient, acceptable sur le plan pharmaceutique, peut être un alcool, un polyol, un dérivé (poly)alcoxy, un alkyl ester d'acide gras, un polyalkylène glycol ou un diméthylsulfoxyde. Le dispositif, dont au moins une partie est en polyester, comprend un élément valve disposé de manière à pulvériser des doses aérosol de ladite composition pharmaceutique vers l'extérieur du récipient.

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