Pharmaceutical compositions and dosage forms for...

A - Human Necessities – 61 – K

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A61K 31/57 (2006.01) A61K 31/56 (2006.01) A61K 31/566 (2006.01) A61K 31/568 (2006.01) A61K 47/22 (2006.01)

Patent

CA 2526616

Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs, particularly steroids, are provided. The pharmaceutical compositions include a therapeutically effective amount of a hydrophobic drug, preferably a steroid; a solubilizer, preferably a vitamin E substance; and a surfactant. The synergistic effect between the hydrophobic drug and the vitamin E substance results in a pharmaceutical formulation with improved dispersion of both the active agent and the solubilizer. As a result of the improved dispersion, the pharmaceutical composition has improved bioavailability upon administration. Methods of improving the bioavailability of hydrophobic drugs administered to a patient are also provided.

L'invention concerne des compositions pharmaceutiques et des formes posologiques pour l'administration de médicaments hydrophobes, en particulier de stéroïdes. Ces compositions pharmaceutiques renferment une quantité thérapeutiquement efficace d'un médicament hydrophobe, de préférence un stéroïde, d'un solubilisant, de préférence une substance de vitamine E, et d'un tensioactif. L'effet synergique entre le médicament hydrophobe et la substance de vitamine E donne lieu à une formulation pharmaceutique à dispersion améliorée de l'agent actif et du solubilisant. Du fait de cette dispersion améliorée, la composition pharmaceutique présente une biodisponibilité améliorée dès son administration. La présente invention concerne également des méthodes permettant d'améliorer la biodisponibilité de médicaments hydrophobes administrés à un patient.

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