A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/55 (2006.01) C07K 14/47 (2006.01) C07K 14/81 (2006.01) C07K 16/18 (2006.01) C07K 16/38 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2058935
Pharmaceutical compositions containing a 57 amino acid protease inhibitor and uses for those compositions are taught. The protease inhibitor is referred to as A4i which is associated with Alzheimer's disease. In addition to the A4i protease, other analogs are taught as are pharmaceutical compositions containing such analogs and their uses in treating a variety of abnormalities associated with Kunitz-type basic protease inhibitors. For example, it has been found that pharmaceutical compositions containing A4i protease and analogs thereof inhibit plasmin and tryptase, and also inhibit pancreatic trypsin, alpha-chymotrypsin, tissue kallikrein and serum kallikrein. In that certain diseases are associated with a general release of proteases such as trypsin, ehymo-trypsin and elastase into the circulatory system pharmaceutical compositions containing A4i and analogs thereof can be used in the management of such diseases.
Compositions pharmaceutiques contenant un inhibiteur de la protéase comptant 57 acides aminés et leurs applications. L'inhibiteur de la protéase est appelé A4i et est associé à la maladie d'Alzheimer. En plus de la protéase A4i, d'autres analogues sont décrits de même que d'autres compositions pharmaceutiques contenant ces analogues et leurs applications dans le traitement de diverses anomalies associées aux inhibiteurs de la protéase de base de type Kunitz. Par exemple, on a constaté que des compositions pharmaceutiques renfermant la proétase A4i et des analogues de celle-ci inhibent la plasmine et la tryptase, de même que que la trypsine pancréatique, l'alpha-chymotrypsine, la kallikréine tissulaire et sérique. Comme certaines maladies sont associées à une libération générale de protéases, telles la trypsine, l'éhymo-trypsine et l'élastase, dans la circulation sanguine, des compositions pharmaceutiques contenant A4i et des analogues peuvent être utilisées dans le traitement de ces maladies.
Cordell Barbara
Katunuma Nobuhiko
Schilling James W.
Battison Williams Dupuis
California Biotechnology Inc.
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