A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/119, 167/228
A61K 31/44 (2006.01) A61K 8/63 (2006.01) A61K 9/06 (2006.01) A61K 31/555 (2006.01) A61K 31/57 (2006.01) A61K 31/58 (2006.01)
Patent
CA 1116082
A B S T R A C T The present invention relates to a novel synergistic composition for the treatment of inflammation in warm blooded animals which comprises an effective amount of bis-(2-pyridyl- 1-oxide) disulfide and/or at least one adduct of bis-12- pyridyl-1-oxide) disulfide having the empirical formula: (C5H4NOS)2MYt (I) wherein M represents a member selected from the group con- sisting of zinc, iron, magnesium, tin, cadmium, zirconium, alkali and alkaline earth metals; Y is the anion of an inor- ganic or organic acid and t is either 1 or 2 in admixture with a pharmaceutical carrier. Bis-(2-pyridyl-1-oxide) disulfide or its adducts have been further found to enhance the anti- inflammatory activity of corticosteroids and non-steroidal anti-inflammatory agents.
311816
Klein Robert W.
Nuss George W. Jr.
Goudreau Gage & Associates
Rorer (william H.) Inc.
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