Pharmaceutical compositions and methods

Details Pharmaceutical compositions and methods Pharmaceutical compositions and methods

A - Human Necessities

61

K

A61K 31/045 (2006.01) A61K 31/047 (2006.01) A61K 31/35 (2006.01) A61K 31/44 (2006.01)

Patent

CA 2266496

Disclosed are methods and compositions for regulating the melanin content of mammalian melanocytes; regulating pigmentation in mammalian skin, hair, wool or fur; treating or preventing various skin and proliferative disorders; increasing the differentiation of mammalian neuronal cells for purposes of treating neurodegenerative diseases or nerve damage; and stimulating cellular nitric oxide (NO) synthesis, cyclic guanosine monophosphate levels (cGMP), and protein kinase G (PKG) activity for purposes of treating diseases mediated by deficiencies in the NO/cGMP/PKG signal transduction pathway; by administration of various compounds, including alcohols, diols and/or triols and their analogues.

L'invention concerne des procédés et de compositions de régulation de la teneur en mélanine de mélanocytes mammaliens; de modulation de la pigmentation de la peau, des poils, de la laine ou de la fourrure de mammifères; de traitement ou de prévention de divers troubles cutanés et proliférants; d'augmentation de la différentiation des cellules neuronales de mammifères pour le traitement de maladies neurodégénératives ou d'atteinte nerveuse; et de stimulation de la synthèse du monoxyde d'azote (NO), des taux de l'acide guanosine-monophosphorique cyclique (GMPc), de l'activité de la protéine kinase G (PKG) en vue du traitement de maladies induites par des déficits dans la voie de transduction du signal de NO/GMPc/PKG. Lesdits procédés consistent à administrer divers composés, dont des alcools, des diols et/ou des triols et leurs analogues.

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