Pharmaceutical compositions and methods for effecting...

C - Chemistry – Metallurgy – 07 – D

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C07D 453/02 (2006.01) A61K 31/44 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2294990

Patients susceptible to or suffering from disorders, such as central nervous system disorders, which are characterized by an alteration in normal neurotransmitter release, such as dopamine release (e.g., Parkinsonism, Parkinson's Disease, Tourette's Syndrome, attention deficient disorder, or schizophrenia) are treated by administering an endo or exo form of a 1-aza-2-(3-pyridyl)bicyclo[2.2.1]heptane, a I-aza-2-(3-pyridyl)bicyclo[2.2.2] octane, a 1-aza-2-(3- pyridyl)bicyclo[3.2.2]nonane, a 1-aza-7-(3-pyridyl) bicyclo[2.2.1]heptane, a 1-aza-3-(3-pyridyl)bicyclo[3.2.2]nonane, or a 1-aza-7-(3- pyridyl)bicyclo[3.2.2]nonane.

La présente invention concerne un traitement destiné à des patients susceptibles de souffrir ou souffrant effectivement de troubles tels que les troubles du système nerveux central, qui sont caractérisés par une altération de la libération normale d'un neurotransmetteur telle que la libération de dopamine (par exemple le parkinsonisme, la maladie de Parkinson, la maladie de Gilles de la Tourette, le déficit de la capacité d'attention ou la schizophrénie). Ce traitement consiste en l'administration de la forme <u>endo</u> ou <u>exo</u> d'un 1-aza-2-(3-pyridyl)bicyclo[2.2.1]heptane, d'un 1-aza-2-(3-pyridyl)bicyclo[2.2.2]octane, d'un 1-aza-2-(3-pyridyl)bicyclo[3.2.2]nonane, d'un 1-aza-7-(3-pyridyl)bicyclo[2.2.1]heptane, d'un 1-aza-3-(3-pyridyl)bicyclo[3.2.2]octane, ou d'un 1-aza-7-(3-pyridyl)bicyclo[3.2.2]nonane.

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