Pharmaceutical compositions and methods for use

Details Pharmaceutical compositions and methods for use Pharmaceutical compositions and methods for use

C - Chemistry, Metallurgy

07

D

C07D 213/74 (2006.01) A61K 31/44 (2006.01) A61K 31/505 (2006.01) C07D 213/26 (2006.01) C07D 213/38 (2006.01) C07D 213/65 (2006.01) C07D 213/70 (2006.01) C07D 213/73 (2006.01) C07D 213/82 (2006.01) C07D 213/89 (2006.01)

Patent

CA 2376061

Pharmaceutical compositions incorporate aryl substituted olefinic amine compounds. Representative compounds are (2S)-(4E)-N-methyl-5-[3-(5-isopropoxy- 1-oxopyridin)yl)]-4-penten-2-amine, (3E)-N-methyl-4-(3-(1-oxopyridin)yl)-3- buten-1-amine, (4E)-N-methyl-5-(3-(1-oxopyridin)yl)-4-penten-2-amine, (4E)-N- methyl-5-(3-(5-((carboxymethyl)oxy)pyridin)yl)-4-penten-2-amine, (3E)-N-methyl- 4-[3-(5-nitro-6-aminopyridin)yl]-3-buten-1-amine, (3E)-N-methyl-4-[3-(5-(N- benzylcarboxamido)pyridin)yl]-3-buten-1-amine(4E)-N-methyl-5-[5-(2- aminopyrimidin)yl]-4-penten-2-amine, (4E)-N-methyl-5-(3-(5-aminopyridin)yl)-4- penten-2-amine (3E)-N-methyl-4-(3-(5-isobutoxypyridin)yl)-3-buten-1-amine, (3E)-N-methyl-4-(3-(5-ethylthiopyridin)yl)-3-buten-1-amine, (4E)-N-methyl-5-(3- (5-trifluoromethylpyridin)yl)-4-penten-2-amine, (4E)-5-(3-(5- isopropoxypyridin)yl)-4-penten-2-amine, and (4E)-5-(3-(5-isopropoxypyridin)yl)- 4-penten-2-amine.

L'invention concerne des compositions pharmaceutiques comprenant des composés aminés oléfiniques à substitution aryle. Les composés représentatifs sont (2S)-(4E)-N-méthyl-5-[3-(5-isopropoxy-1-oxopyridine)yl)]-4-pentène-2-amine, (3E)-N-méthyl-4-(3-(1-oxopyridine)yl)-3-butène-1-amine, (4E)-N-méthyl-5-(3-(1-oxopyridine)yl)-4-pentène-2-amine, (4E)-N-méthyl-5-(3-(5-((carboxyméthyl)oxy)pyridine)yl)-4-pentène-2-amine, (3E)-N-méthyl-4-[3-(5-nitro-6-aminopyridine)yl]-3-butène-1-amine, (3E)-N-méthyl-4-[3-(5-(N-benzylcarboxamido)pyridine)yl]-3-butène-1-amine(4E)-N-méthyl-5-[5-(2-aminopyrimidine)yl]-4-penten-2-amine, (4E)-N-méthyl-5-(3-(5-aminopyridin)yl)-4-penten-2-amine (3E)-N-méthyl-4-(3-(5-isobutoxypyridine)yl)-3-butène-1-amine, (3E)-N-méthyl-4-(3-(5-éthylthiopyridine)yl)-3-butène-1-amine, (4E)-N-méthyl-5-(3-(5-trifluorométhylpyridine)yl)-4-pentène-2-amine, (4E)-5-(3-(5-isopropoxypyridine)yl)-4-pentène-2-amine, et (4E)-5-(3-(5-isopropoxypyridine)yl)-4-pentène-2-amine.

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