Pharmaceutical compositions and methods for use

Details Pharmaceutical compositions and methods for use Pharmaceutical compositions and methods for use

A - Human Necessities

61

K

A61K 31/444 (2006.01) A61P 25/00 (2006.01) C07D 471/18 (2006.01)

Patent

CA 2317567

A pharmaceutical composition incorporating a nicotinic antagonist is provided. The composition is an effective amount of a compound of formula (I), wherein X' is nitrogen or carbon bonded to a substituent species characterized as having a sigma m value greater than 0, less than 0 or 0; X is nitrogen or carbon bonded to a substituent species characterized as having a sigma m value greater than 0, less than 0 or 0; A, A' and A" are individually substituent species characterized as having a sigma m value greater than 0, less than 0 or 0; Z' is a substituent other than hydrogen; j is an integer from 0 to 5; and the wavy line in the structure indicates that the compound can exist in the form of an enantiomer or a diasteromer; Z" is hydrogen or a substituent other than hydrogen; Y is C=O, C(OH)R' or C-A, where R' is hydrogen or lower alkyl.

L'invention porte sur une préparation pharmaceutique comportant un antagoniste de la nicotine consistant en une dose agissante d'un composé de formule (I) dans laquelle: X' est N ou C lié à un substituant présentant un .SIGMA.m supérieur, inférieur, ou égal à zéro; X est N ou C lié à un substituant présentant un .SIGMA.m égal à zéro; A, A' et A'' sont individuellement des substituants présentant un .SIGMA.m supérieur, inférieur, ou égal à zéro; Z' est un substituant autre que H; j est un entier de 0 à 5; la ligne brisée de la structure indique que le composé existe sous forme d'énantiomère ou de diastéromère; Z'' est H ou un substituant autre que H; Y est C=O, C(OH)R' ou C-A, R' étant H ou alkyle inférieur.

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