Pharmaceutical compositions and methods for use

Details Pharmaceutical compositions and methods for use Pharmaceutical compositions and methods for use

C - Chemistry, Metallurgy

07

C

C07C 211/49 (2006.01) A61K 31/04 (2006.01) A61K 31/05 (2006.01) A61K 31/085 (2006.01) A61K 31/135 (2006.01) A61K 31/165 (2006.01) A61K 31/36 (2006.01) C07C 211/29 (2006.01) C07C 215/46 (2006.01) C07C 217/54 (2006.01) C07C 233/43 (2006.01) C07C 243/02 (2006.01) C07D 317/58 (2006.01)

Patent

CA 2384094

Pharmaceutical compositions aryl substituted amine compounds, and in particular, 3-aminophenyl amine compounds are provided. Representative compounds are (4E)-N-methyl-5-(3-acetamido-4-methylphenyl)-4-penten-2-amine, (4E)-N-methyl-5-(3-amino-4-methylphenyl)-4-penten-2-amine, (4E)-N-methyl-5-(3- (dimethylamino)phenyl)-4-penten-2-amine, (4E)-N-methyl-5-(4-methyl-3- nitrophenyl)-4-penten-2-amine, (4E)-N-methyl-5-(3-fluorophenyl)-4-penten-2- amine, (4E)-N-methyl-5-(3,4-dichlorophenyl)-4-penten-2-amine and (4E)-N-methyl- 5-(3,4-methylenedioxyphenyl)-4-penten-2-amine.

Cette invention se rapporte à des compositions pharmaceutiques constituées par des composés amine à substitution aryle et en particulier par des composés 3-aminophényl-amine. Les composés représentatifs sont (4E)-N-méthyl-5-(3-acétamido-4-méthylphényl)-4-pentène-2-amine, (4E)-N-méthyl-5-(3-amino-4-méthylphényl)-4-pentène-2-amine, (4E)-N-méthyl-5-(3-(diméthylamino)phényl)-4-pentène-2-amine, (4E)-N-méthyl-5-(4-méthyl-3-nitrophényl)-4-pentène-2-amine, (4E)-N-méthyl-5-(3-fluorophényl)-4-pentène-2-amine, (4E)-N-méthyl-5-(3,4-dichlorophényl)-4-pentène-2-amine et (4E)-N-méthyl-5-(3,4-méthylènedioxyphényl)-4-pentène-2-amine.

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