Pharmaceutical compositions and methods of treating dry eye...

Details Pharmaceutical compositions and methods of treating dry eye... Pharmaceutical compositions and methods of treating dry eye...

A - Human Necessities

61

K

A61K 31/519 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2691914

Inhibitors of Janus kinase-3 ("Jak3") are useful for treating dry eye disorders and other disorders requiring the wetting of the eye. Jak3 inhibitors useful for treating eye disorders include the compound 3- { (3R,4R)-4-Methyl-3-[methyl-(7H-pyrrolo[2,3- d]pyrimidin-4-yl)-amino]-piperidin-1-yl}-3-oxo-propionitrile.

L'invention porte sur des inhibiteurs de Janus kinase-3 ('Jak3') qui sont utiles pour traiter des troubles de l'il sec ou autres troubles nécessitant l'humidité de l'il. Les inhibiteurs de Jak3 utiles pour traiter des troubles oculaires comprennent le composé 3-{(3R,4R)-4-méthyl-3-[méthyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-pipéridin-1-yl}-3-oxo-propionitrile.

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