Pharmaceutical compositions as inhibitors of dipeptidyl...

Details Pharmaceutical compositions as inhibitors of dipeptidyl... Pharmaceutical compositions as inhibitors of dipeptidyl...

C - Chemistry, Metallurgy

07

D

C07D 207/16 (2006.01) A61K 31/401 (2006.01) A61K 31/4439 (2006.01) A61K 31/506 (2006.01) A61P 37/02 (2006.01) C07D 207/27 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2497725

The present invention relates to compounds of formula I which inhibit dipeptidyl peptidase IV (DPP-IV) and are useful for the prevention or treatment of diabetes, especially type II diabetes, as well as hyperglycemia, Syndrome X, hyperinsulinemia, obesity, atherosclerosis, and various immunomodulatory diseases. Or pharmaceutically acceptable salts or prodrugs thereof, wherein X,R,R1,R2 and R3 have the definitions given in the description.

La présente invention porte sur des composés qui inhibent la peptidase IV dipeptidyl (DPP-IV) et sont utiles dans la prévention ou le traitement des diabètes, notamment les diabètes non-insulino dépendants, et de l'hyperglycémie, le Syndrome X, l'hyperinsulinémie, l'obésité, l'athérosclérose et diverses maladies immuno-modulatrices.

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