C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/258, 260/242
C07D 213/67 (2006.01) A61K 31/44 (2006.01) A61K 31/455 (2006.01) A61K 31/505 (2006.01) A61K 31/52 (2006.01) C07D 473/00 (2006.01) C07H 19/167 (2006.01)
Patent
CA 1219582
ABSTRACT OF THE DISCLOSURE A pharmaceutical composition and process for providing the same are provided herein. The composition is one in which a serotonin precursor, e.g., 5-hydroxytryptophane or derivatives of 5-hydroxytryptophane having the formula: Image wherein R preferably represents hydrogen (to provide 5-hydroxytrytophane); or a C1-C12 alkyl group; or a C5-C16 alicyclic, monocyclic aromatic hydrocarbyl, or polycyclic aromatic hydrocarbyl group (e.g. methyl, propyl, pentyl, octyl, dodecal, n-butyl, t-butyl, cyclopentyl, cyclohexyl, decalinyl, perhydroanthryl, 4-methylcyclohexyl, phenyl, p-isopropylphenyl, benzyl, alkyl-substituted benzyl, naphthyl, anthryl, phenanthryl, halo, or hydroxyl), is chemically associated with a nitrogenous heterocyclic derivative of a purine, pyrimidine or pyridine base, e.g., inosine, theophylline, theobromine, allopurinol, pyridoxine, hypoxanthine, folic acid, adenine, nicotinamide, caffeine or orotic acid. Such salt or complex has been found to be suitable for increasing cerebral serotonin concentrations.
411517
Laruelle Claude
Lepant Marcel
Borden Ladner Gervais Llp
S.a. Panmedica
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