A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/415 (2006.01) A61K 31/045 (2006.01) A61K 31/426 (2006.01) A61P 3/00 (2006.01) A61P 9/00 (2006.01)
Patent
CA 2650566
The invention is directed to pharmaceutical compositions comprising pharmacologically effective quantities of each of a) at least one KATP channel modulator as a first active agent and b) at least one CBx modulator as a second active agent. The invention further relates to the use of such compositions and to methods of treating, preventing, delaying progression of, delaying onset of and/or inhibiting a variety of disease conditions including obesity, diabetes mellitus, metabolic syndrome, syndrome X, insulinoma, familial hyperinsulemic hypoglycemia, male pattern baldness, detrusor hyperreactivity, asthma, neuroprotection, epilepsy, analgesia, cardioprotection, angina, cardioplegia, arrhythmia, coronary spasm, peripheral vascular disease, cerebral vasospasm, appetite regulation, neurodegeneration, pain - including neuropathic pain and chronic pain - and impotence in mammals and humans by administering such compositions to subjects in need thereof. The invention also is directed to processes of manufacturing such compositions.
L'invention concerne des compostions pharmaceutiques contenant des quantités pharmaceutiquement efficaces a) d'au moins un modulateur de canal KATP servant de premier agent actif et b) d'au moins un modulateur de CBx servant de deuxième agent actif. L'invention concerne également l'utilisation de telles compositions et des procédés de traitement, de prévention, de retardement de la progression, de retardement du déclenchement et/ou d'inhibition d'une pluralité de troubles tels que l'obésité, le diabète sucré, le syndrome métabolique, le syndrome X, l'insulinome, l'hypoglycémie hyperinsulémique familiale, l'alopécie androgénétique, l'hyperréactivité du détrusor, l'asthme, la neuroprotection, l'épilepsie, l'analgésie, la cardioprotection, l'angine de poitrine, la cardioplégie, l'arythmie, les spasmes coronariens, les maladies vasculaires périphériques, les vasospasmes cérébraux, la régulation de l'appétit, la neurodégénération, les douleurs telles que les douleurs neuropathiques et chroniques, et l'impuissance chez l'homme et les mammifères, par administration de telles compositions à des sujets nécessitant un tel traitement. L'invention concerne également des procédés de fabrication de telles compositions.
Antel Jochen
Firnges Michael
Gregory Peter-Colin
Lange Josephus Hubertus Maria
Reiche Dania
Mccarthy Tetrault Llp
Solvay Pharmaceuticals Gmbh
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