Pharmaceutical compositions comprising cyclosporins

Details Pharmaceutical compositions comprising cyclosporins Pharmaceutical compositions comprising cyclosporins

A - Human Necessities

61

K

167/103.8

A61K 38/13 (2006.01) A61K 9/107 (2006.01) A61K 9/48 (2006.01)

Patent

CA 1332150

ABSTRACT Pharmaceutical compositions comprising a cyclosporin, e.g. Ciclosporin or [Nva]2-Ciclosporin, in "microemulsion pre-concentrate" and microemulsion form. The compositions typically comprise (1.1) a C1-5alkyl or tetrahydrofurfuryl di- or partial-ether of a low molecular weight mono- or poly-oxy-alkane diol, e.g. Transcutol or Glycofurol, as hydrophilic component. Compositions are also provided comprising a cyclosporin and (1.1) and, suitably, also a saccharide monoester, e.g. raffinose or saccharose monolaurate. Dosage forms include topical formulations and, in particular, oral dosage forms.

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