C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 215/38 (2006.01) A61K 31/16 (2006.01) A61K 31/22 (2006.01) A61K 31/40 (2006.01) A61K 31/435 (2006.01) A61K 31/47 (2006.01) C07C 239/16 (2006.01) C07C 259/06 (2006.01) C07D 213/75 (2006.01) C07D 233/88 (2006.01)
Patent
CA 2090426
2090426 9300082 PCTABS00019 Pharmaceutical compositions comprising compounds of the formula: R2C CH2O(CH2)nCO[NR3CHR(CH2)mCO]qNOHR1 3, wherein R is hydrogen, alkyl optionally substituted by OR5, SR5, NR5R6, COR6, COOR6, CONR5R6, -NHC(NR5R6)=NR7, aryl, aralkyl or heteroaryl; R1, R2 and R3 are independently selected from the group consisting of hydrogen, alkyl, aralkyl, aryl, COOR4, CONHR4 and CONR4R4; R2 may additionally be alkyl susbstituted by alkoxy, alkenyloxy or by a group -O-(CH2)p-COOX or -O-(CH2)p-CONHX, wherein p is an integer from 1 to 10 and X is alkyl, aralkyl, aryl or heteroaryl; R4, R5 and R6 are hydrogen, alkyl, aralkyl, aryl or heteroaryl; n is 1 or 2; m is 0, 1 or 2 and q is 0 or 1, and when m is 0, the moiety -NR3CHR- may be a pyrrolidine ring, or a pharmaceutically acceptable salt thereof, are useful for removal of iron (III) from mammalian cells and iron (III)-dependent organisms and for treatment of iron (III) overload and disorders caused by iron (III)-dependent pathogenic organisms, such as Plasmodium falciparum that causes malaria.
Cabantchik Ioav Z.
Libman Jacqueline
Shanzer Abraham
Borden Ladner Gervais Llp
Ltd. Yeda Research And Development Co.
Yissum Research And Development Company Of The Hebrew University
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