Pharmaceutical compositions comprising imatinib and a...

Details Pharmaceutical compositions comprising imatinib and a... Pharmaceutical compositions comprising imatinib and a...

A - Human Necessities

61

K

A61K 9/20 (2006.01) A61K 9/16 (2006.01) A61K 31/506 (2006.01)

Patent

CA 2606602

Sustained release pharmaceutical compositions that contain imatinib or a pharmaceutically acceptable salt thereof. The pharmaceutical compositions further contain a release retardant, for example a water soluble, a water swellable and/or a water insoluble polymer. The present invention also features a particularly useful process of making such sustained release pharmaceutical compositions by using an extruder.

L'invention concerne des compositions pharmaceutiques à libération prolongée qui contiennent de l'imatinibe ou un sel de l'imatinibe pharmaceutiquement acceptable. Lesdites compositions pharmaceutiques renferment en outre un retardateur de libération, par exemple un polymère soluble dans l'eau, hydrogonflable et/ou insoluble dans l'eau. L'invention concerne enfin un procédé particulièrement utile de fabrication de telles compositions pharmaceutiques à libération prolongée qui utilise une extrudeuse.

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