Pharmaceutical compositions comprising interferon-tau

Details Pharmaceutical compositions comprising interferon-tau Pharmaceutical compositions comprising interferon-tau

A - Human Necessities

61

K

A61K 38/21 (2006.01)

Patent

CA 2558803

Methods of modulating cytokine levels in a human subject by administering interferon-tau (IFN.tau.) are described. More specifically, a method of up- regulating the interleukin 10 (IL-10) level in patients afflicted with a condition that responds to treatment by having an increased blood IL-10 level, such as an autoimmune condition, a viral infection, or a condition of cellular proliferation by administering IFN.tau. is described. Also described are methods of modulating blood levels of interleukin-12 (IL-12) and interferon- gamma (IFN-.gamma.) by administering IFN.tau.. In various embodiments, IFN.tau. is administered alone or in combination with a second therapeutic agent.

La présente invention concerne des procédés pour moduler des concentrations de cytokine chez un être humain qui consistent à administrer de l'interféron tau (IFN.tau.). De manière plus spécifique, cette invention concerne un procédé pour augmenter la concentration d'interleukine 10 (IL-10) chez des patients atteints d'une pathologie qui répond à un traitement lorsque la concentration sanguine de IL-10 est augmentée, par exemple une pathologie auto-immune, une infection virale ou une pathologie de la prolifération cellulaire, par administration de IFN.tau.. En outre, cette invention concerne des procédés pour moduler des concentrations sanguines d'interleukine 12 (IL-12) et d'interféron gamma (IFN-.gamma.) par administration de IFN.tau.. Dans divers modes de réalisation, IFN.tau. est administré seul ou combiné à un second agent thérapeutique.

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