Pharmaceutical compositions comprising metal complexes

Details Pharmaceutical compositions comprising metal complexes Pharmaceutical compositions comprising metal complexes

C - Chemistry, Metallurgy

07

F

C07F 15/00 (2006.01) A61K 31/28 (2006.01) A61K 31/295 (2006.01) A61K 31/555 (2006.01) A61P 35/00 (2006.01) C07F 19/00 (2006.01)

Patent

CA 2367282

A compound of the formula [Ma(XbL)cYdZe]nt~ wherein: M is a metal ion or a mixture of metal ions; X is a cation or a mixture of cations; L is a ligand, or mixture of ligands each containing at least two different donor atoms selected from the elements of Group IV, Group V or Group VI of the Periodic Table; Y is a ligand or a mixture of the same or different ligands each containing at least one donor atom or more than one donor atom selected from the elements of Group IV, Group V or Group VI of the Periodic Table; and Z is a halide or pseudohalide ion or a mixture of halide ions and pseudohalide ions; and wherein: a=1-3; b=0-12; c=0-18; d=0-18; e=0-18; and n=0-10; provided that at least one of c, d and e is 1 or more; wherein c is 0: b is also 0; wherein a is 1: c, d and e are not greater than 9; and wherein a is 2: c, d and e are not greater than 12.

La présente invention concerne un composé représenté par la formule générale [M¿a?(X¿b?L)¿c?Y¿d?Z¿e?]?nt±¿. Dans cette formule, M est un ion métallique ou un mélange d'ions métalliques. X est un cation ou un mélange de cations. L est un ligand ou un mélange de ligands contenant chacun au moins deux atomes donneurs différents appartenant aux éléments des Groupes IV, V ou VI de la classification périodique des éléments. Y est un ligand ou un mélange de ligands identiques ou différents contenant chacun au moins un atome donneur appartenant aux éléments des Groupes IV, V ou VI de la classification périodique des éléments. Z est un ion halogénure ou pseudo-halogénure ou un mélange d'ions halogénure et d'ions pseudo-halogénure. En outre, a=1-3, b=0-12, c=0-18, d=0-18, e=0-18, et n=0-10. Toutefois l'un au moins de c, d et e doit valoir au moins 1. De plus, si c vaut 0, b vaut aussi 0. Si a vaut 1, c, d et e ne doivent pas être supérieurs à 9. Enfin, si a vaut 2, c, d et e ne doivent pas être supérieurs à 12.

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