Pharmaceutical compositions comprising nep-inhibitors,...

Details Pharmaceutical compositions comprising nep-inhibitors,... Pharmaceutical compositions comprising nep-inhibitors,...

A - Human Necessities

61

K

A61K 31/55 (2006.01) A61K 31/54 (2006.01) A61K 45/06 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2596922

A novel combination therapy is described for cardiovascular diseases or conditions, by administering a synergistic combination of at least one inhibitor of neutral endopepti- dase, at least one inhibitor of the endogenous endothelin producing system and at least one diuretic, preferably a thiazide diuretic or an adenosine A1 antagonist.

La présente invention décrit un nouveau traitement combiné pour les maladies ou troubles cardiovasculaires, qui consiste à administrer une association synergique composée d~au moins un inhibiteur de l~endopeptidase neutre, au moins un inhibiteur du système de production de l~endothéline endogène et au moins un diurétique, de préférence un diurétique thiazide ou un antagoniste de l~adénosine A1.

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