Pharmaceutical compositions comprising nep-inhibitors,...

A - Human Necessities – 61 – K

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A61K 31/00 (2006.01) A61K 31/4178 (2006.01) A61K 31/4184 (2006.01) A61K 31/55 (2006.01) A61K 45/06 (2006.01) A61P 9/00 (2006.01) A61P 9/12 (2006.01)

Patent

CA 2579716

A novel combination therapy is described for cardiovascular diseases, in particular essential hypertension, pulmonary hypertension and/or congestive heart failure, involving administering a synergistic combination of at least one inhibitor of neutral endopeptidase, at least one inhibitor of the endogenous endothelin producing system and at least one AT1 receptor antagonist.

L'invention concerne une nouveau traitement combiné pour les maladies cardiovasculaires, en particulier l'hypertension artérielle essentielle, l'hypertension pulmonaire et/ou l'insuffisance cardiaque congestive, impliquant l'administration d'une combinaison synergique d'au moins un inhibiteur de l'endopeptidase neutre, d'au moins un inhibiteur du système de production de l'endothéline endogène et d'au moins un antagoniste du récepteur AT1.

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