Pharmaceutical compositions comprising nitric...

A - Human Necessities – 61 – K

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A61K 47/48 (2006.01) A61K 31/785 (2006.01)

Patent

CA 2205564

A polymeric composition capable of releasing nitric oxide under physiological conditions which includes a biopolymer, such as a peptide, polypeptide, protein, oligonucleotide or nucleic acid, to which is bound a nitric oxide-releasing N2O2- functional group; pharmaceutical compositions comprising the polymeric composition; and method of treating biological disorders in which dosage with nitric oxide is therapeutic.

Une composition polymère, pouvant libérer de l'oxyde nitrique dans des conditions physiologiques, comprend un biopolymère, tel qu'un peptide, un polypeptide, une protéine, un oligonucléotide ou un acide nucléique, auquel est lié groupe foncitonnel N2O2<-> libérant de l'oxyde nitrique. On décrit aussi des compositions pharmaceutiques comprenant cette condition polymère, et des procédés qui permettent de traiter des troubles biologiques par un dosage thérapeutique de l'oxyde nitrique.

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