A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/51 (2006.01) A61K 31/198 (2006.01) A61K 31/216 (2006.01) A61K 31/277 (2006.01) A61K 31/282 (2006.01)
Patent
CA 2530736
The present invention relates to a pharmaceutical composition of a biologically active agent and a block copolymer composed of a poly(ethylene oxide) forming hydrophilic segment and a poly(butyl (alkyl)acrylate-co- (alkyl)acrylic acid) that is capable of forming supramolecular assemblies or micelles under favourable conditions. The supramolecular assemblies or micelles formed from said polymers associate or dissociate reversibly upon changes in the environmental pH. The pharmaceutical compositions of the present invention contain hydrophobic drugs, cations or polycationic compounds, which can be delivered to the body by oral route or other routes of administration.
La présente invention concerne une composition pharmaceutique d'un agent biologiquement actif et un copolymère séquencé constitué d'un oxyde de (poly)éthylène formant un segment hydrophile et un acide poly(butyl (alkyl)acrylate-co-(alkyl)acrylique qui est capable de former des ensembles supramoléculaires ou micelles dans des conditions favorables. Les ensembles supramoléculaires ou micelles formés à partir de ces polymères s'associent ou se dissocient de manière réversible lors de changements de l'environnement pH. Les compositions pharmaceutiques selon la présente invention contiennent des médicaments hydrophobes, des cations ou composés polycationiques qui peuvent être délivrés à l'organisme par voie orale ou autres voies d'administration.
Leroux Jean-Christophe
Sant Vinayak
Borden Ladner Gervais Llp
Universite de Montreal
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