Pharmaceutical compositions comprising synthetic peptide...

Details Pharmaceutical compositions comprising synthetic peptide... Pharmaceutical compositions comprising synthetic peptide...

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 38/16 (2006.01) A61L 27/22 (2006.01)

Patent

CA 2355400

Compositions and methods for treating and preventing host-versus-graft disease and graft-versus-host disease comprising as active ingredient random copolymers of amino acids comprising one amino acid from at least three of the following groups: (a) lysine and arginine; (b) glutamic acid and aspartic acid; (c) alanine and glycine; and (d) tyrosine and tryptophan; with the proviso that the random copolymer is not Copolymer 1 or D-Copolymer 1 when the disease being treated is graft-versus-host disease.

L'invention concerne des compositions et des méthodes de traitement et de prévention de la réaction du greffon contre l'hôte et de la réaction de l'hôte contre le greffon, qui comprennent comme matière active des copolymères aléatoires d'acides aminés dont l'un est sélectionné dans au moins trois des groupes suivants : (a) lysine et arginine ; (b) acide glutamique et acide aspartique ; (c) alanine et glycin ; et (d) tyrosine et tryptophan ; à condition que le copolymère aléatoire ne soit pas le copolymère 1 ou le copolymère D 1 lorsque la maladie à traiter est la réaction de l'hôte contre le greffon.

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