A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4365 (2006.01) A61K 31/496 (2006.01) A61K 31/5355 (2006.01) A61K 31/55 (2006.01) A61P 7/02 (2006.01) A61P 29/00 (2006.01) C07D 495/04 (2006.01) C07D 497/04 (2006.01)
Patent
CA 2515102
The present invention provides thieno[2,3-C]pyridine derivatives, pharmaceutical compositions comprising the thieno[2,3-C]pyridine derivatives, and methods of use thereof. The compounds capable of inhibiting glycosaminoglycan (GAG) interactions with effector cell adhesion molecules (ECAM) are useful for treating diseases and disorders mediated by GAG-ECAMs interactions, particularly inflammatory and autoimmune diseases, viral diseases, cancer, and amyloid disorders.
La présente invention se rapporte à des dérivés thiéno[2,3-c]pyridine, à des compositions pharmaceutiques comportant ces dérivés thiéno[2,3-c]pyridine, et à des procédés d'utilisation de ces compositions. Les composés capables d'inhiber les interactions des glycosaminoglycanes (GAG) avec des molécules d'adhérence aux cellules effectrices (ECAM) sont utiles pour le traitement des maladies et des troubles dont la médiation est assurée par les interactions GAG-ECAM, notamment les maladies inflammatoires et auto-immunes, les maladies virales, le cancer et les troubles amyloïdes.
Gregor Paul
Harris Nicholas
Koppel Juraj
Zhuk Regina
LandOfFree
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